Process for preparing preparations for oral administration

Details Process for preparing preparations for oral administration Process for preparing preparations for oral administration

1976-02-03

1978-07-18

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 78, 424 81, A61K 916, A61K 3174, A61K 3178

Patent

active

041016513

ABSTRACT:
A process for preparing preparations for oral administration which do not have a bitter taste which comprises either dissolving a bitter taste-masking substance at a high concentration in a solvent to be used for dissolving or suspending a bitter active ingredient and adding the active ingredient to the resulting solution followed by kneading, or kneading a solution or suspension in which a bitter active ingredient has been dissolved or suspended with the bitter taste-masking substance, adding silicic acid anhydride to the resulting kneaded substance to form a powder and granulating the powder using a solution of the bitter taste-masking substance in a fluidized bed granulator.

REFERENCES:
patent: 3242049 (1966-03-01), O'Brien et al.
patent: 3247065 (1966-04-01), Koff
patent: 3859228 (1975-01-01), Morishita et al.
patent: 3860733 (1975-01-01), Morse et al.
patent: 3879511 (1975-04-01), Goodhart et al.
patent: 3891570 (1975-06-01), Fukushima et al.
patent: 3906086 (1975-09-01), Guy et al.
Remington's Practice of Pharmacy, 13th Ed. (1965), Mack Pub. Co., Easton, Pa., p. 559.
Martin-Husa's Pharmaceutical Dispensing, (1966), Mack Pub. Co., Easton, Pa., pp. 67-73 & 109-111.

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