Process for preparing L(-)-carnitine chloride

Details Process for preparing L(-)-carnitine chloride Process for preparing L(-)-carnitine chloride

1990-10-09

1993-09-28

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435127, 435132, 435135, 435280, 435123, 4352521, C12P 1300, C12P 1500, C12P 762, C12P 700

Patent

active

052486010

ABSTRACT:
A biotechnological process for preparing L(-)-carnitine chloride, having the formula ##STR1## comprising: (a) reacting a racemic ester of (R,S)-3,4-epoxybutyric acid having the formula ##STR2## wherein R is an alkyl group having from 1 to 10 carbons or a benzyl group, with an enzyme capable of selectively hydrolyzing enantiomer S(-);

REFERENCES:
patent: 4371618 (1983-02-01), Cavazza
patent: 4642290 (1987-02-01), Sih
patent: 4732853 (1988-03-01), Whitesides et al.
Fritz et al., Carnitine Acetyltransferase, Biological Chemistry, vol. 249, No. 5, pp. 2188-2192 (May 1965).
Row et al., L-Carnitine Therapy in Propionicacidaemia, Lancet, Jun. 19, 1982, pp. 1411-1412.
Barel et al., "Comparative Studies of the Enzymatic Properties of Novo and Carlsberg Subtilisins", J of Biol. Chem., vol. 243, No. 7 Apr. 10 pp. 1344-1348 1968.
Joues et al. "Techniques of Chemistry", vol. X, (ed), Part 1, 1976, Wiley, pp. 137-167.

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