Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1993-03-03
1996-06-25
Chambers, Jasemine C.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 800DIG2, 800DIG3, 424 92, 424 937, 4351723, C12N 1500, A61K 4900
Patent
active
055301797
ABSTRACT:
The invention features a transgenic mouse having a substantial deficiency in functionally active natural killer cells and T lymphocytes which is useful as a model system for immune diseases, tumorigenesis and transplant rejection.
REFERENCES:
patent: 5175384 (1992-12-01), Krimpenfort et al.
Ashwell et al., "Genetic And Mutational Analysis Of The T-Cell Antigen Receptor," Annu. Rev. Immunol. 8:139-167, 1990.
Baniyash et al., "Disulfide Linkage Of The .zeta. And .eta. Chains Of The T Cell Receptor," The Journal of Biological Chemistry 263:9874-9878, 1988.
Barry et al., "Successful Engraftment Of Human Postnatal Thymus In Severe Combined Immune Deficient (SCID) Mice: . . . Immunosuppressive Regimens," J. Exp. Med. 173:167-180, 1991.
Biron et al., "Murine Natural Killer Cells Stimulated In Vivo Do Not Express The T Cell Receptor .alpha., .beta., .gamma., T3.delta., Or T3.epsilon. Genes," The Journal of Immunology 139:1704-1710, 1987.
Blumberg et al., "Structure Of The T-Cell Antigen Receptor: Evidence For Two CD3 .epsilon. Subunits In The T-Cell Receptor-CD3 Complex," Proc. Natl. Acad. Sci. USA 87:7220-7224, 1990.
Brombacher et al., "Elimination of CD8+0 Thymocytes In Transgenic Mice Expressing An Anti-LYT2.2 Immuno-Globulin Heavy Chain Gene," The Embo Journal 8:3719-3726, 1989.
Clevers et al., "Characterization And Expression Of The Murine CD3-.epsilon. Gene," Proc. Natl. Acad. Sci. USA 85:98623-8627, 1988.
Clevers et al., "An Enhance Located In A CpG-Island 3' To The TCR/CD3-.epsilon. Gene Confers T Lymphocyte-Specificity To Its Promoter," The EMBO Journal 8:2527-2535, 1989.
Clevers et al., "Human CD3-.epsilon. Gene Contains Three Miniexons And Is Transcribed From A Non-Tata Promoter," Proc. Natl. Acad. Sci. USA 85:8156-8160, 1988.
Correa et al., "Most .gamma..delta. T Cells Develop Normally In .beta..sub.2 -Microglobulin-Deficient Mice," Proc. Natl. Acad. Sci. USA 89:653-657, 1992.
Cosgrove et al., "Mice Lacking MHC Class II Molecules," Cell 66:1051-1066, 1991.
de la Hera et al., "Structure Of The T Cell Antigen Receptor (TCR): Two CD3.epsilon. Subunits In A Functional TCR/CD3 Complex," J. Exp. Med. 173:7-17, 1991.
Finkel et al., "The Thymus Has Two Functionally Distinct Populations Of Immature .alpha..beta.+ T Cells: One Population Is Deleted By Ligation of .alpha..beta.TCR,"Cell 58:1047-1054, 1989.
Finkel et al., "Immature Thymocytes Are Protected From Deletion Early In Ontogeny," Proc. Natl. Acad. Sci. USA 89:3372-3374, 1992.
Finkel et al., "T-Cell Development And Transmembrane Signaling: Changing Biological Responses Through An Unchanging Receptor," Immunology Today 12:79-85, 1991.
Gold et al., "Evolutionary Relationship Between The T3 Chains Of The T3 Chains Of The T-Cell Receptor Complex And The Immunologlobulin Supergene Family," Proc. Natl. Acad. Sci. USA 84:7649-7653, 1987.
Gold et al., "Isolation Of cDNA Clones Encoding The 20K Non-Glycosylated Polypeptide Chain Of The Human T-Cell Receptor/T3 Complex," Nature 321:431-434, 1986.
Grusby et al., "Depletion Of CD4+ T Cells In Major Histocompatibility Complex Class II-Deficient Mice," Science 253:1417-1420, 1991.
Hanahan, "Transgenic Mice As Probes Into Complex System," Science 246:1265-1275, 1989.
Huesmann et al., "Kinetics And Efficacy Of Positive Selection In The Thymus Of Normal And T Cell Receptor Transgenic Mice," Cell 66:533-540, 1991.
Kamel-Reid et al., "A Model Of Human Acute Lymphoblastic Leukemia In Immune-Deficient SCID Mice," Science 246:1597-1600, 1989.
Kamel-Reid et al., "Engraftment Of Immune-Deficient Mice With Human Hematopoietic Stem Cells," Science 242:1706-1709, 1988.
Kelley, "Gene Therapy In Humans: A New Era Begins," Annals of Internal Medicine 114:697-698, 1991.
Kishi et al., "Surface Expression Of The .beta. T Cell Receptor (TCR) Chain In The Absence Of Other TCR Or CD3 Proteins On Immature T Cells," The EMBO Journal 10;93-100, 1991.
Kisielow et al., "Tolerance In T-Cell-Receptor Transgenic Mice Involves Deletion Of Nonmature CD4+8+ Thymocytes," Nature 333:742-746, 1988.
Klausner et al., "T Cell Antigen Receptor Activation Pathways: The Tyrosine Kinase Connection" Cell 64:875-878, 1991.
Koller et al., "Normal Development Of Mice Deficient In .beta..sub.2 M, MHC Class I Proteins, And CD 8+ T Cells," Science 248:1227-1230, 1990
Krimpenfort et al., "T Cell Depletion In Transgenic Mice Carrying A Mutant Gene For TCR-.beta.," Nature 341:742-746, 1989.
Kruisbeek et al., "Early Development Of The T Cell Repertoire," Journal of Experimental Medicine 157:1932-46, 1983.
Kruisbeek et al., "Absence Of The LYT-2.sup.-,L3T4+ Lineage Of T Cells In Mice Treated Neonatally . . . With I-A-Bearing Antigen-Presenting Cell Function," Journal of Experimental Medicine 161:1029-1047, 1985.
Kyoizumi et al., "Implantation And Maintenance Of Functional Human Bone Marrow In SCID-Hu Mice," Blood 79:1704-1711, 1992.
Lanier et al., "The Developmental Relationship Between NK Cells And T Cells," Immunology Today 13:392-395, 1992.
Lanier et al., "Expression Of Cytoplasmic CD3.epsilon. Proteins In Activated Human Adult Natural Killer (NK) Cells And CD3.gamma.,.delta.,.epsilon. Complexes In Fetal NK Cells," The Journal of Immunology 149:1876-1880, 1992.
Lanier et al., "C0-Association Of CD3.zeta. With A Receptor (CD16) For IgG Fc On Human Natural Killer Cells" Nature 342:803-805, 1989.
Lesley et al., "The Pgp-1 Antigen Is Expressen On Early Fetal Thymocytes," Immunogenetics 22:149-157, 1985.
Letourneur et al., "Activation Of T Cells by A Tyrosine Kinase Activation Domain In The Cytoplasmic Tail Of CD3.epsilon.," Science 255:79-82, 1992.
Marusic-Galesic et al., "Development Of CD4.sup.31 CD8+ Cytotoxic T Cells Requires Interactions With Class I MHC Determinants," Nature 333:180-183, 1988.
McCune et al., "The SCID-hu Mouse: Murine Model for The Analysis Of Human Hematolymphoid Differentiation And Function," Science 241:1632-1639, 1988.
McGarry et al., "The Cooperative Effect Of The Satin and Beige Mutations In The Suppression Of NK And CTL Activities In Mice," Immunogenetics 20:527-534, 1984.
Mercep et al., "Activation-Driven Programmed Cell Death And T Cell Receptor .zeta..eta. Expression," Science 246:1162-1165, 1989.
Mombaerts et al., "Mutations In T-Cell Antigen Receptor Genes .alpha. And .beta. Block Thymocyte Development At Different Stages," Nature 360:225-231, 1992.
Mombaerts et al., "RAG-1 Deficient Mice Have No Mature B And T Lymphocytes," Cell 68:869-877, 1992.
Mosier et al., "Transfer Of A Functional Human Immune System To Mice with Severe Combined Immunodeficiency," Nature 335:256-259, 1988.
Mosier et al., "Human Immunodeficiency Virus Infection Of Human-PBL14 SCID Mice," Science 251:791-794, 1991.
Mosier, "Immunodeficient Mice Xenografted With Human Lymphoid Cells: New Models For In Vivo Studies Of Human Immunobiology And Infectious Diseases," J. of Clinical Immunology 10:185-191, 1990.
Murphy et al., "Induction By Antigen Of Intrathymic Apoptosis Of CD4.sup.+ CD8.sup.+ TCR.sup.1.smallcircle. Thymocytes In Vivo," Science 250:1720-1723, 1990.
Namikawa et al., "Infection Of The SCID-hu Mouse By HIV-1," Science 242:1684-1686, 1988.
Peault et al., "Lymphoid Reconstitution Of The Human Fetal Thymus In SCID Mice With CD34.sup.+ Precursor Cells," J. Exp. Med. 174:1283-1286, 1991.
Pereira et al., "Blockade Of Transgenic .gamma..delta. T Cell Development In .beta..sub.2 -Microglobulin Deficient Mice," the Embo Journal 11:25-31, 1992.
Perussia et al., "Murine Natural Killer Cells Express Functional Fc.gamma.R.alpha. Gene," J. Exp. Med. 170:73-86, 1989.
Phillips et al., "Ontogeny Of Human Natural Killer (NK) Cells: Fetal NK Cells Mediate Cytolytic Function And Express Cytoplasmic CD3.epsilon.,.delta. Proteins," J. Exp. Med. 175:1055-1066, 1992.
Philpott et al.,"Lymphoid Development In Mice Congenitally Lacking T Cell Receptor .alpha..beta. -Expressing Cells," Science 256:1448-1452, 1992.
Reth, "Antigen Receptor Tail Clue," Nature 338:383-384, 1989.
Roder et al., "The Beice Mutation In The Mouse Selectively Impairs Natural Killer Cell Function," Nature 278:451-453, 1979.
Rodewald et al., "A Population Of Early Fetal Thymocytes Exp
Terhorst Cornelius P.
Wang Bao-ping
Beth Israel Hospital Association
Chambers Jasemine C.
LandOfFree
Transgenic immunodeficient animal models does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transgenic immunodeficient animal models, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic immunodeficient animal models will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2190378