Process for preparing cephalosporanic acid derivatives

Details Process for preparing cephalosporanic acid derivatives Process for preparing cephalosporanic acid derivatives

1978-03-31

1979-11-20

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 30, C07D50120

Patent

active

041751850

ABSTRACT:
A process for preparing a cephalosporanic acid derivative or a 7-acylaminocephalosporanic acid derivative which comprises subjecting an esterifying agent to reaction in liquid sulfur dioxide in the presence of a base with an N-protected-cephalosporin C to obtain a diester, subjecting the diester to reaction in an inert solvent with an iminohalide forming agent to produce an iminohalide, subjecting the iminohalide with a lower alcohol to produce an iminoether, subjecting the product produced, after subjecting the iminoether to reaction with a reactive derivative of an organic acid, to hydrolysis and further eliminating the ester group of the carboxylic acid.

REFERENCES:
patent: 4022773 (1977-05-01), Ishimaru
patent: 4074047 (1978-02-01), Foxtun et al.
patent: 4079180 (1978-03-01), Susuki et al.

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