Process for preparing bupropion hydrochloride

Details Process for preparing bupropion hydrochloride Process for preparing bupropion hydrochloride

2008-07-07

2010-06-15

Keys, Rosalynd (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S396000

Reexamination Certificate

active

07737302

ABSTRACT:
This invention described a synthesis method of bupropion hydrochloride. m-chloropropiophenone was brominated directly with bromine, then aminated with t-butylamine and finally reacted with HCl to obtain crude product of bupropion hydrochloride. Pure product was obtained after recrystallization. This method is convenient and suitable for commercial manufacturing because of low cost of production, high yield, less byproducts and being environmental friendly.

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patent: WO 2004/024674 (2004-03-01), None
XU1 CASREACT 148:217184, 2006. Abstract of (Studies on the synthesis of bupropion hydrochloride; Anhui Daxue Xuebao, Ziran Kexueban (2006), 30(5), 87-90.).
XU2 CASREACT 148:217184, 2006. Abstract of (Studies on the synthesis of bupropion hydrochloride; Anhui Daxue Xuebao, Ziran Kexueban (2006), 30(5), 87-90.).
Dandala et al., Derwent abstract of IN 200401323 I4, published Jun. 22, 2007.
Ke et al. “Studies on the Synthesis of Bupropion hydrocholorid.” Chinese Journal of Medicinal Chemistry, vol. 13, No. 5, Oct. 2003, pp. 286-287 (Translation and Abstract).
Musso et al. “Synthesis and Evaluation of the Anticonvulsant Activity of a Series of 2-Amino-1-Phenyl-1-Propanols Derived From the Metalbolites of the Antidepressant Bupropion.” Bioorganic & Medicinal Chemistry Letters, vol. 7, No. 1, 1997. pp. 1-6.
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