Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2008-07-07
2010-06-15
Keys, Rosalynd (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S396000
Reexamination Certificate
active
07737302
ABSTRACT:
This invention described a synthesis method of bupropion hydrochloride. m-chloropropiophenone was brominated directly with bromine, then aminated with t-butylamine and finally reacted with HCl to obtain crude product of bupropion hydrochloride. Pure product was obtained after recrystallization. This method is convenient and suitable for commercial manufacturing because of low cost of production, high yield, less byproducts and being environmental friendly.
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XU1 CASREACT 148:217184, 2006. Abstract of (Studies on the synthesis of bupropion hydrochloride; Anhui Daxue Xuebao, Ziran Kexueban (2006), 30(5), 87-90.).
XU2 CASREACT 148:217184, 2006. Abstract of (Studies on the synthesis of bupropion hydrochloride; Anhui Daxue Xuebao, Ziran Kexueban (2006), 30(5), 87-90.).
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Chen Guoliang
Ge Yangxiang
He Chun
Li Fengying
Lu Chengyue
Jacobson & Holman PLLC
Keys Rosalynd
Zhejiang Apeloa Medical Technology Co., Ltd.
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