Process for preparing 1,4-benzodiazepines

Details Process for preparing 1,4-benzodiazepines Process for preparing 1,4-benzodiazepines

1975-07-24

1977-08-23

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602393D, C07D24316

Patent

active

040440036

ABSTRACT:
1,4-Benzodiazepine derivatives of the formula, ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl, a haloalkyl, a cycloalkylalkyl, an alkoxyalkyl, an acyloxyalkyl, an alkylthioalkyl, an alkylaminoalkyl, a dialkylaminoalkyl, a hydroxyalkyl, carbamoyl, or an N-alkylcarbamoyl; R.sub.2 is hydrogen or a lower alkyl; X is hydrogen, a halogen, nitro, or trifluoromethyl; A is a group of the formula, ##STR2## (wherein Y and Z each represent hydrogen, a halogen, a lower alkyl, or nitro) and a salt thereof, are prepared by reacting a 1,4-benzodiazepin-2-one compound of the formula, ##STR3## wherein R.sub.1, R.sub.2, X, Y and Z are the same as defined above, with diborane in an inert solvent.

REFERENCES:
patent: 3144439 (1964-08-01), Reeder et al.
Archer et al., Chem. Reviews, vol. 68, p. 766, (1968).
Feuer et al., J. Org. Chem., vol. 30, pp. 2877-2880, (1965).
Brown et al., J. Am. Chem. Soc., vol. 86, pp. 3566-3567, (1964).
Ishizumi et al., J. Org. Chem., vol. 37, pp. 4111-4113, (1972).

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