Process for preparing 1,4,8,11-tetraazacyclotetradecane

Details Process for preparing 1,4,8,11-tetraazacyclotetradecane Process for preparing 1,4,8,11-tetraazacyclotetradecane

1995-08-02

1997-03-04

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540450, 540470, C07D25502

Patent

active

056080611

ABSTRACT:
An improved process for preparing 1,4,8,11-tetraazacyclotetradecane comprising the tetratosylation of an acyclic tetraamine to obtain a tetratoluenesulfonamide compound in a first step, the cyclization of said sulfonamide compound to obtain tetratosyl cyclam in a second step, and the detosylation of tetratosyl cyclam in a third step followed by basification to obtain the desired 1,4,8,11-tetraazacyclotetradecane.

REFERENCES:
patent: 5021409 (1991-06-01), Murrer et al.
patent: 5047527 (1991-09-01), Handel et al.
patent: 5284944 (1994-02-01), Madison et al.
patent: 5386028 (1995-01-01), Tilstam et al.
J. Med. Chem., vol. 38, No. 2, pp. 366-378 (1995).

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