Process for preparation of stable amorphous macrolide antibiotic

Details Process for preparation of stable amorphous macrolide antibiotic Process for preparation of stable amorphous macrolide antibiotic

1977-10-14

1978-11-28

Rosen, Sam

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 35, 424115, 424181, 424362, A61K 3174, A61K 3500

Patent

active

041276477

ABSTRACT:
Amorphous solids of macrolide antibiotics which are stable with the passage of time are prepared by dissolving a macrolide antibiotic and a cellulose polymer selected from the group consisting of ethyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose as a stabilizing substance in a volatile organic solvent selected from the group consisting of dichloromethane, 1,1,1-trichloroethane and chloroform and spray drying the resulting solution.

REFERENCES:
patent: 3962419 (1976-06-01), Mayama et al.

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