Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2007-03-27
2007-03-27
Page, Thurman K. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
Reexamination Certificate
active
10497899
ABSTRACT:
A process for producing gabapentin, (1-(aminomethyl)-1-cyclohexaneacetic acid) from gabapentin hydrochloride salt. In the disclosed process, the gabapentin hydrochloride is converted to gabapentin using an inorganic base, such as barium hydroxide. Gabapentin hydrochloride is converted to gabapentin sulfate which in turn is converted to free base using barium hydroxide. The process is directed to improvement in the manufacture of gabapentin which would be industrially feasible and effective. Gabapentin obtained following the process of the invention is suitable as a drug especially in the treatment of cerebral diseases such as epilepsy.
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Kirk-Othmer Encyclopedia of Chemical Technology © 1993 by John Wiley & Sons, Inc. All Online Posting Date: Aug. 17, 2001.
Gupta Rajender Pershad
Joshi Rajesh Dilip
Naik Rajesh Vinodrai
Rajshekhar Araddy
Saigal Jagdish Chand
Carpenter John W.
Henson Michael R.
Martin Timothy J.
Nicholas Piramal India Limited
Page Thurman K.
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