Process for preparation of Gabapentin

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

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Reexamination Certificate

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10497899

ABSTRACT:
A process for producing gabapentin, (1-(aminomethyl)-1-cyclohexaneacetic acid) from gabapentin hydrochloride salt. In the disclosed process, the gabapentin hydrochloride is converted to gabapentin using an inorganic base, such as barium hydroxide. Gabapentin hydrochloride is converted to gabapentin sulfate which in turn is converted to free base using barium hydroxide. The process is directed to improvement in the manufacture of gabapentin which would be industrially feasible and effective. Gabapentin obtained following the process of the invention is suitable as a drug especially in the treatment of cerebral diseases such as epilepsy.

REFERENCES:
patent: 4024175 (1977-05-01), Satzinger et al.
patent: 4894476 (1990-01-01), Butler et al.
patent: 5068413 (1991-11-01), Steiner et al.
patent: 5095148 (1992-03-01), Mettler et al.
patent: 5132451 (1992-07-01), Jennings et al.
patent: 6255526 (2001-07-01), Pesachovich et al.
patent: 6576790 (2003-06-01), Tenconi et al.
patent: 0 340 677 (1989-11-01), None
patent: WO 98/28255 (1998-07-01), None
patent: WO 02/44123 (2000-06-01), None
patent: WO 00/58268 (2000-10-01), None
Kirk-Othmer Encyclopedia of Chemical Technology © 1993 by John Wiley & Sons, Inc. All Online Posting Date: Aug. 17, 2001.

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