Process for N-acylation of 7 amino cephem compounds

Details Process for N-acylation of 7 amino cephem compounds Process for N-acylation of 7 amino cephem compounds

1975-02-13

1976-10-26

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260470, 260481R, 260471A, 260478, 260479S, 260485R, C07D50106

Patent

active

039883264

ABSTRACT:
A compound having the formula: ##EQU1## and a 7-amihocephalosporanic acid derivative having the formula: ##SPC1##
Are reacted in a homogeneous aqueous solution of the reactants to prepare a reaction of the formula: ##SPC2##
In the formulas, R may be H or other defined substituents such as carboxyl group; R.sub.1 is H, an alkyl of 1-4 carbons or other defined substitents; R.sub.2 is H or phenyl or when taken together with R.sub.1 form a defined cyclicradical; R.sub.3 is H or other defined substituents and M is an alkali metal cation, ammonium cation or H.

REFERENCES:
patent: 3864340 (1975-02-01), Ishimaru et al.
Clayton et al., "J. of the Chem. Soc.," 1957, pp. 1398-1407.

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