Process for making HIV protease inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544137, 544360, 544364, 544373, 544374, 544390, 546146, 546147, 548217, 549552, C07D40906, C07D40914, C07D40506, C07D24104

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056189397

ABSTRACT:
A process is disclosed for making a chiral compound of the formula ##STR1## comprising reacting an epoxide compound of the formula ##STR2## and an amide of the formula ##STR3## in the presence of a strong base at a low temperature.

REFERENCES:
patent: 5026853 (1991-06-01), Van Daele et al.
patent: 5075337 (1991-12-01), Cordi et al.
patent: 5169952 (1992-12-01), Askin et al.
patent: 5218114 (1983-06-01), Bock et al.
patent: 5461154 (1995-10-01), Jungheim et al.
patent: 5463067 (1995-10-01), Askin et al.
patent: 5484926 (1996-01-01), Dressman et al.
patent: 5491238 (1996-02-01), Askin et al.
Askin, D., et al., J. Org. Chem., 1992, 57, 2771-2773.
Baldwin, J.E., et al., J. Chem. Soc., Chem. Commun., 1992, 1249-1251.
Burgess, K., et al., j. Org. Chem. 1992, 57, 5931-5936.
Felder, E., et al., Helvetica Chim. Acta, 1960, 43, 888.
Hanson, R.M., Chem. Rev., 1991, 91, 437-475.
J. Klunder, et al., J. Org. Chem., 1989, 54, 1295-1304.
Kohl, N.E., et al., Proc. Nat'l Acad. Sci., 1988, 85, 4686.
M. Figueredo, et al., Tetrahedron, 1987, 43, 1881-1886.
Pearl, L.H. et al., Nature, 1987, 329, 351.
Pirrung, M.C., et al., Helvetica Chimica Acta, 1989, 72, 1301-1310.
Power, M.D., et al., Science, 1986, 231, 1567.
Ratner, L. et al., Nature, 1985, 313, 277.
Toh, H. et al., EMBO J., 1985, 4, 1267.
Kageyama et al, Antimicrobial Agents and Chemotherapy, 36, pp. 926-933 (1992).
Winslow et al, AIDS, 8, pp. 753-756 (1994).
Barton et al, Tetrahedron: Asymmetry, 3, pp. 1189-1196 (Sep. 1992).
Protective Groups in Organic Synthesis by Theodora Greene, pp. 223-224, 232 (1981).
Canas et al, Tetrahedron Letters, 32, pp. 6931-6934 (1991).
Mulzer et al, Liebigs. Ann. Chem., pp. 445-448 (1988).

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