Process for making 2-(4-isobutylphenyl)propionic acid and relate

Details Process for making 2-(4-isobutylphenyl)propionic acid and relate Process for making 2-(4-isobutylphenyl)propionic acid and relate

1978-12-26

1980-01-29

Torrence, Dolph H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

260465R, 260651HA, 562492, C07C 6333, C07C 6352

Patent

active

041862708

ABSTRACT:
Pure 2-(4-isobutylphenyl)propionic acid and related compounds are obtained in good yield by a multi-step process comprising chloromethylation of benzene or an alkylbenzene, conversion of the resulting benzyl chloride to the cyanide, alkylation of that product to the phenylpropionitrile or phenylbutyronitrile, reaction of unreacted benzyl cyanide with an aldehyde to inhibit its hydrolysis, and hydrolysis of the nitrile to the free acid. The products are antiinflammatory, antipyretic, and analgesic drugs.

REFERENCES:
patent: 3228831 (1966-01-01), Nicholson et al.
patent: 3385886 (1968-05-01), Nicholson et al.
patent: 4031243 (1977-06-01), Aparicio et al.
patent: 4056509 (1977-11-01), Verbrugge et al.

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