Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2005-04-05
2005-04-05
Naff, David M. (Department: 1651)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S093700, C435S180000, C435S395000, C435S396000, C435S402000
Reexamination Certificate
active
06875442
ABSTRACT:
A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a range of about 1.0-2.0 mm. The polymer scaffold is prepared using a novel process which advantageously combines the techniques of particulate leaching and phase inversion to render a process that provides amplified means by which to control the morphology of the resulting polymer scaffold. The polymer scaffold has utility in the area of tissue engineering, particularly as a scaffold for both in vitro and in vivo cell growth.
REFERENCES:
patent: 5041138 (1991-08-01), Vacanti et al.
patent: 5228994 (1993-07-01), Tkacik et al.
patent: 5338772 (1994-08-01), Bauer et al.
patent: 5489335 (1996-02-01), Unosawa et al.
patent: 5498335 (1996-03-01), Moya
patent: 5514378 (1996-05-01), Mikos et al.
patent: 0747068 (1996-12-01), None
“Porosity and Specific Surface of Bone” by Martin RB in CRC Critical Reviews in Biomedical Engineering, 10(3), 179-22, 1984.
K. Whang et al., “A Novel Method to Fabricate Bioabsorbable Scaffolds”,Polymer, vol. 36, No. 4, pp 837-842, 1995 Elsevier Science Ltd.
Mooney et al., “Novel Approach to Fabricate Porous Sponges of Poly(D,L-lactic-co-glycolic acid) Without the Use of Organic Solvents”,Biomaterials, vol. 17, pp. 1417-1422, 1996 Elsevier Science Ltd.
Thompson et al., “Fabrication of Biodegradable Polymer Scaffolds to Engineer Trabecular Bone”,J. Biomater. Sci. Polymer Edn., vol. 7, No. 1, pp. 23-38, 1995 VSP.
Mikos et al., “Laminated Three-Dimensional Biodegradable Foams for Use in Tissue Engineering”,Biomaterials, vol. 14, No. 5, pp. 323-330, 1993 Butterworth-Heinemann Ltd.
Schugens et al., “Polylactide Macroporous Biodegradable Implants for Cell Transplantation. II. Preparation of Polylactide Foams by Liquid-Liquid Phase Separation”,Journal of Biomedical Materials Research, vol. 30, pp. 449-461, 1996 by John Wiley & Sons.
Ishaug-Riley et al., “Three-Dimensional Culture of Rat Calvarial Osteoblasts in Porous Biodegradable Polymers”,Biomaterials, vol. 19, pp. 1405-1412, 1998 Elsevier Science Ltd.
Ishaug et al., “Bone Formation by Three-Dimensional Stromal Osteoblast Culture in Biodegradable Polymer Scaffolds”,Journal of Biomedical Materials Research, vol. 36, pp. 17-28, 1997 John Wiley & Sons, Inc.
Mooney et al., “Novel Approach to Fabricate Porous Sponges of Poly (D,L-Lactic-Co-Glycolic Acid) Without the Use of Organic Solvents”, BIOMATERIALS, vol. 17, No. 14, Elsevier Science Limited 1996, pp. 1417-1422.
Davies John E.
Holy Chantal E.
Shoichet Molly S.
Bonetec Corporation
Hill & Schumacher
Naff David M.
Schumacher Lynn C.
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