Process for extracting and purifying morphine from opium

Details Process for extracting and purifying morphine from opium Process for extracting and purifying morphine from opium

1996-11-19

2000-04-25

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48900

Patent

active

060545844

ABSTRACT:
A process for extracting morphine from opium is described. In the process, opium is extracted with a basic alcoholic solution. The basic alcoholic solution is filtered and the alcohol removed from the filtrate to leave a residue. The residue is then extracted with a basic aqueous solution having a pH of at least 11. The basic aqueous solution may be filtered to remove any solid matter remaining after the aqueous extraction step, and then be stirred with a sufficient amount of a salt to avoid emulsion formation. The basic aqueous solution or filtrate is then extracted with benzene or toluene. Next, adjusting the pH of the basic aqueous filtrate to pH 8.5 to 9.5 allows the morphine to precipitate and be recovered.

REFERENCES:
patent: 1048712 (1912-12-01), Lloyd
patent: 2715627 (1955-08-01), Mehltretter et al.
Loeffler. Chem Abstr vol. 62, Entry 11640 b abstr. DD 28733, 1965.
Trojanek, Chem Abstr vol. 98 Entry 81d0 abstr Czech 197403, 1982.
Bentley Chemistry of the Morphine Alkaloids, Oxford, Clarendon Press, p. 16, 1954.

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