Process for enzymatic production of isomerically pure isosorbide

Details Process for enzymatic production of isomerically pure isosorbide Process for enzymatic production of isomerically pure isosorbide

1994-02-04

1996-07-23

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435876, 435921, 435931, C12P 4100

Patent

active

055388914

ABSTRACT:
Process for the enzymatic production of isomerically pure compounds having the general formulae I and II ##STR1## in which the substituents R have the meanings stated in the claims, as well as their use for the production of isomerically pure isosorbide-2-nitrate having the formula V and isosorbide-5-nitrate having the formula VI, ##STR2## which are both important as therapeutic agents for coronary diseases.

REFERENCES:
patent: 5032523 (1991-07-01), Amano et al.
Okumura S et al, BBA 575:156-165 (1979).
Hills M et al, BBA 1042:237-240 (1990).
Langrand G et al, Tet. Letts 27:29-32 (1986).
Seemayer, et al, "Enzymatic Preparation of Isomerically Pure 1,4:3,6-Dianhydro-D-Glucitol Monoacetates precursors for Isoglucitol 2 and 5 mononitrates", Tetrahedron: Asymmetry, vol. 3, No. 9, pp. 1123-1126 (Sep. 1991).
Nishio, et al., "Enzymatic transesterification with the lipase from Pseudomonas fragi 22.39 B in a non-aqueous reaction system", J. biochem. 104: 681-682 (Nov. 1988).
Wang, et al., "Lipase catalyze irreversible transesterification using enol esters as acylating reagents: preparative enantio-and regioselective synthesis of alcohols, glyercol derivatives, sugars and organometallics", J. Am. Chem. Soc. 110:7200-7205 (1988).

Affiliated with

Also associated with

Rating

Process for enzymatic production of isomerically pure isosorbide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for enzymatic production of isomerically pure isosorbide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for enzymatic production of isomerically pure isosorbide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-712423