Crystalline quinapril and a process for producing the same

Details Crystalline quinapril and a process for producing the same Crystalline quinapril and a process for producing the same

1987-03-30

1988-08-02

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544344, C07D21716

Patent

active

047614790

ABSTRACT:
A novel crystalline form of quinapril and a novel process for the large scale preparation of the ACE inhibitor, quinapril, in a highly pure state. The substance is of high bulk density suitable for formulation in capsules and tablets. This inexpensive process uses HCl gas in glacial acetic acid for rapid and clean de-t-butylation at room temperature.

REFERENCES:
patent: 4294832 (1981-10-01), Yoneda et al.
patent: 4344949 (1982-08-01), Hoefle et al.

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