Process for cleaning large bone grafts and bone grafts produced

Surgery – Means for introducing or removing material from body for... – Material introduced into and removed from body through...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

128898, 623 16, A61M 3100

Patent

active

058205810

ABSTRACT:
A process for removing substantially all bone marrow from a large bone and a bone graft produced thereby. A large substantially intact bone is selected and excess cartilage is removed from at least one articulating surface of the bone. An opening is prepared through the cortical layer of the bone to permit access of a vacuum line to the bone cavity. A vacuum line is attached to the bone via the opening for application of vacuum to the bone cavity, and the opening is sealed. A vacuum is applied to draw a first cleaning solution through the bone cavity so as to draw the first solution and solubilized bone marrow through the vacuum line to exit the bone at the opening. The vacuum is discontinued when the bone has been substantially cleaned of bone marrow. Subsequently, a second flushing solution may be drawn through the bone cavity via vacuum.

REFERENCES:
patent: 4020183 (1977-04-01), Asculai et al.
patent: 4169123 (1979-09-01), Moore et al.
patent: 4207689 (1980-06-01), Romera-Sierra et al.
patent: 4258722 (1981-03-01), Sessions et al.
patent: 4315919 (1982-02-01), Shanbrom
patent: 4366822 (1983-01-01), Alshuler
patent: 4412985 (1983-11-01), Shanbrom
patent: 4456589 (1984-06-01), Holman et al.
patent: 4526751 (1985-07-01), Gartner
patent: 4553974 (1985-11-01), Dewajnee
patent: 4637931 (1987-01-01), Schmitz
patent: 4678470 (1987-07-01), Nashef et al.
patent: 4695536 (1987-09-01), Lindstrom et al.
patent: 4801299 (1989-01-01), Brendel et al.
patent: 4891221 (1990-01-01), Shanbrom
patent: 4923677 (1990-05-01), Simon et al.
patent: 4946792 (1990-08-01), O'Leary
patent: 4975526 (1990-12-01), Kuberasampath et al.
patent: 4994030 (1991-02-01), Glowczewskie et al.
patent: 5037437 (1991-08-01), Matsen, III
patent: 5041055 (1991-08-01), Roth
patent: 5047030 (1991-09-01), Draenert
patent: 5106626 (1992-04-01), Parsons et al.
patent: 5118512 (1992-06-01), O'Leary et al.
patent: 5120656 (1992-06-01), O'Leary et al.
patent: 5133756 (1992-07-01), Bauer et al.
patent: 5167961 (1992-12-01), Lussi et al.
patent: 5186945 (1993-02-01), Shanbrom
patent: 5192282 (1993-03-01), Draenert
patent: 5333626 (1994-08-01), Morse et al.
patent: 5454815 (1995-10-01), Geisser et al.
patent: 5513662 (1996-05-01), Morse et al.
Helenius, A. et al., "Solubilization of Membranes by Detergents", Biochimo Biophys, Acta 415, 1975.
Skrinnyuk, P. "Method of Extracting Bone Marrow Cells and Preserving Solutions From Spongy Bone Transplant Material", Committee on Inventions and Discoveries, Council of Ministers, USSR, Aug. 1982.
Co-pending U.S. Patent application No. 08/646,520, filed May 7, 1996.
Sattar et al., "Survival and Disinfectant Inactivation of the Human Immunodeficiency Virus: A Critical Review", RID 1991; 13 (May-Jun.), pp. 430-447.
Exact. excerpts from "Product Specification, Discription, Patent Application & Supporting Documentation", by EXOxEMIS, Inc., Feb. 1991.
Klebanoff et al., "Virucidal Activity of H202-generating Bacteria; Requirement for Peroxidase and Halide", Dept. of Medicine, University of Washington School of Medicine, Seattle, Washington, Sep. 24, 1973.
"DMIN Asceptic Tissue Demineralization", a product brochure from Osteotech, Inc. 1993.
"Maximum Security for You and Your Patent", a product brochure regarding VIP Bone, from Cryolife, Inc. Feb. 12, 1992.
"The Virucidal Capacity of a Surfactant/Iodophor-Based Viral Inactivation Process for Bone Allografts", a report of studies designed and funded by Cryolife, Inc. undated.
Withrow et al., "Evaluation of the Antiretroviral Effect of Various Methods of Sterilization/Preserving Cortiocancellous Bone", Presented at the 36th Annual Meeting, Orthopaedic Research Society, Feb. 5-8, 1990, New Orleans,Louisianna, Transactions of the Orthopaedic Research Society, 16, 1990, pp. 226.
Garrison et al., "Comparison of Bacterial Contimation of Cadaveric Bone Allograft Collected Under Operating Room and Morgue Condition with and without the use of Decontaminating Process", presented at the Second Congress of the Europrean Asscocation of Tissue Bank, Athena, Greece, May 1993.
Morse, "A New Surfactant/Iodophor-Based Viral Inactivation Process (VIP) for Preparation of Bone Allografts", presented at the 16th Annual Meeting of the American Association of TIssue Banks, San Diego, Aug. 1992.
"Improve Performance of Your Immunoassay Systems and Immunodiagnostics Kits", a product brochure by Medicine & Applied Sciences, Inc. undated.
"Viral Inactivation Agent for Blood Samples", an article referring to an Oct. 1990 issue of American Clinical Laboratory entitled Antiviral Agent for General Use in Biological Samples.
Virginia Tissue Bank Procedure Manual, Section 5.9.4.5, Copyright registered on Aug. 6, 1986.
Buck et al., "Human Immunodeficiency Virus Cultured From Bone. Implications for Transplantation", Clinical Orthopaedics and Related Research, No. 251, 1990.
Navy Tissue Bank, Tissue Bank Coordinator Manual 10. "Procurement of Deep Tissues and Bones", p. 9. (undated)
Shutkin, "Homologous-Serum Hepatitis following the Use of Refrigerated Bone-Bank Bone", The Journal of Bone and Joint Surgery, vol. 16-1, No. 1, 1954.
Hyatt et al., "Bone Grafting. The Procurement, Storage, and Clinical Use of Bone Homografts", The American Academy of Orthopaedic Surgeons, Ann Arbor, U.S.A., 1957.
"Transmission of HIV through Bone Transplantation: Case Report and Public Health Recommendations", Morbidity and Mortality Weekly Report, vol. 37, No. 39, 1988.
Kakaiya et al., "Tissue Transplant-Transmitted Infections", Transfusion, vol. 31, No. 3, 1991.
Tomford et al., "A Study of the Clinical Incidence of Infections in the Use of Banked Allograft Bone", The Journal of Bone and Joint Surgery, vol. 63-A, No. 2, 1981.
Furlini et al., "Antibody Response to Human Immunodeficiency Virus after Infected Bone Marrow Transplant", Eur. J. Clin, Microbiol. Infect. Dist., vol. 7, 1988.
Lord et al., "Infection in Bone Allografts. Incidence, Nature, and Treatment", The Journal of Bone and Joint Surgery, vol. 70-A, No. 3, 1988.
Bonfiglio et al., "The Immune Concept: Its Regulation To Bone Transplantation", Annals New York Academy of Sciences, 1955.
Doppelt et al., "Operational and Financial Aspects of A Hospital Bone Bank", The Journal of Bone and Joint Surgery, vol. 63-A, No. 9, 1981.
Dirschi et al., "Topical Antibiotic Irrigation in the Prophylaxis of Operative Wound Infections in Orthopedic Surgery", Orthopedic Infection, vol. 22, No. 3, Jul. 1991.
Reynolds et al., "Clinical Evaluation of the Merthiolate Bone Bank and Homogenous Bone Grafts", The Journal of Bone and Joint Surgery, vol. 33-A, No. 4, 1951.
"Med Clean Mark II", a product brochure by Advanced International Marketing for a unit which includes a pressurized stream of water for bone debridement. (undated).
U.S. Department of Health and Human Services/Public Health Service, "Transmission of HIV Through Bone Transplantation: Case Report and Public Health Recommendations," Morbidity and Morality Weekly Report, 37, 1988, pp. 597-599.
Mellonig, J. T. et al., "HIV Inactivation in a Bone Allograft", J. Periodontology, Dec. 1992, vol. 63, pp. 979-983.
Helinus et al., "Solubilization of Membranes by Detergents", Biochim, Biophys. Acta 415 (1975) 29-79.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process for cleaning large bone grafts and bone grafts produced does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for cleaning large bone grafts and bone grafts produced , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for cleaning large bone grafts and bone grafts produced will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-308794

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.