Process for 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolid

Details Process for 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolid Process for 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolid

1986-02-14

1988-05-03

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2605005H, 540355, C07D26308

Patent

active

047421762

ABSTRACT:
An improved process for the manufacture of herbicidal 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone by cyclizing 3-chloro-N-hydroxy-2,2-dimethylpropanamide with an alkaline or alkaline earth hydroxide at a pH of 7.5 to 9.5, benzylating the resulting 4,4-dimethyl-3-isoxazolidinone, eliminating by-product 1-[(2-chlorophenyl)methoxy]-3,3-dimethyl-2-azetidinone by contacting the product mixture with anhydrous hydrogen chloride, and further benzylating free isoxazolidinone with base.

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