Process and intermediate for the preparation of terazosin hydroc

Details Process and intermediate for the preparation of terazosin hydroc Process and intermediate for the preparation of terazosin hydroc

1994-10-18

1996-04-02

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23984, A61K 31505

Patent

active

055042074

ABSTRACT:
A process for the preparation of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (terazosin hydrochloride dihydrate comprises the steps of reacting 4-amino-2-chloro-6,7-dimethoxy-quinazoline with N-(2-tetrahydrofuroyl)piperazine in an anhydrous polar organic solvent in the absence of an added acid scavenger to produce anhydrous 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (Form IV) and thereafter converting the product of that step to 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine hydrochloride dihydrate.

REFERENCES:
patent: 4026894 (1977-05-01), Winn et al.
patent: 4112097 (1978-09-01), Winn et al.
patent: 4251532 (1981-02-01), Roteman
patent: 4816455 (1989-03-01), Schikaneder et al.
patent: 5212176 (1993-05-01), Kyncl et al.
patent: 5294615 (1994-03-01), Meyer et al.
patent: 5362730 (1994-11-01), Bauer et al.

Affiliated with

Also associated with

Rating

Process and intermediate for the preparation of terazosin hydroc does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process and intermediate for the preparation of terazosin hydroc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process and intermediate for the preparation of terazosin hydroc will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2017320