Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2009-03-06
2011-12-13
Kifle, Bruck (Department: 1622)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
active
08076475
ABSTRACT:
The present invention generally relates to a novel process for preparing vitronectin receptor antagonist compounds having a benzodiazepinyl core structure. This invention relates to the preparation of pharmaceutically active compounds which inhibit the vitronectin receptor and are useful for treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as osteoporosis. In particular, the present invention relates to a novel process for preparing (±)-3-oxo-8-{[3-(pyridin-2-ylamino)propyl]oxy}-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid, (R)-3-oxo-8-{[3-(pyridin-2-ylamino)propyl]oxy}-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid and (S)-3-oxo-8-{[3-(pyridin-2-ylamino)propyl]oxy}-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid or a pharmaceutically acceptable salt thereof.
REFERENCES:
patent: 2003/0050493 (2003-03-01), Peters et al.
patent: 2006/0194786 (2006-08-01), Conde et al.
GlaxoSmithKline LLC
Hsu Grace C.
Kifle Bruck
Lemanowicz John
LandOfFree
Process does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4308215