Recombinant human albumin-interleukin-11 fusion protein with...

Details Recombinant human albumin-interleukin-11 fusion protein with... Recombinant human albumin-interleukin-11 fusion protein with...

2008-09-02

2011-12-27

Mertz, Prema (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

C530S351000, C530S402000

Reexamination Certificate

active

08084021

ABSTRACT:
Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide having a biological function in vitro or in vivo, and preferably, having a therapeutic activity when administered to a human. By fusing the bioactive molecule to HSA, stability of the bioactive molecule in vivo can be improved and the therapeutic index increased due to reduced toxicity and longer-lasting therapeutic effects in vivo. In addition, manufacturing processes are provided for efficient, cost-effective production of these recombinant proteins in yeast.

REFERENCES:
patent: 5116964 (1992-05-01), Capon et al.
patent: 6905688 (2005-06-01), Rosen et al.
patent: 7141547 (2006-11-01), Rosen et al.
patent: 7482013 (2009-01-01), Ballance et al.
patent: WO 01/79443 (2001-10-01), None
Paul et al (1990) Proc. Natl. acad. Sci USA, vol. 87, pp. 7512-7516.
Kendra et al in “Pharmacokinetics and stability of the ch1.4.18-interleukin-2 fusion protein in mice” Cancer Immunol Immuother (1999) 48:219-229.

Affiliated with

Also associated with

Rating

Recombinant human albumin-interleukin-11 fusion protein with... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant human albumin-interleukin-11 fusion protein with..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant human albumin-interleukin-11 fusion protein with... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4308216