Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2006-11-14
2006-11-14
Brumback, Brenda (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S069100, C435S358000, C435S252300, C435S252330, C435S254110, C435S254200, C435S320100, C530S350000, C536S023100, C536S023500
Reexamination Certificate
active
07135334
ABSTRACT:
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
REFERENCES:
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patent: WO 02/102993 (2002-12-01), None
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Accession No. HSDJ144C9(Hall, R.), Creation Date Jul. 2, 1999.
Baker Kevin P.
Ferrara Napoleone
Gerber Hanspeter
Gerritsen Mary E.
Goddard Audrey
Barnes Elizabeth M.
Brumback Brenda
Dreger Ginger R.
Genentech Inc.
Kresnak Mark T.
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