PRMTs as modifiers of the p53 pathway and methods of use

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

Reexamination Certificate

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C435S193000

Reexamination Certificate

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07049088

ABSTRACT:
Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.

REFERENCES:
patent: 6060250 (2000-05-01), Lal et al.
patent: 6471959 (2002-10-01), Lal et al.
patent: 6743614 (2004-06-01), Stallcup et al.
patent: WO 03/102143 (2003-12-01), None
Chen et al. (Jun. 25, 1999) Science, vol. 284, pp. 2174-2177.
Chen, D., et al., “Mus musculus protein arginine methyltransferase (Carm1) mRNA, complete cds.” Genbank GI No. 5257220, Jun. 29, 1999.
NCBI Annotation Project, “Homo sapienscoactivator-associated arginine methyltransferase-1 (CARM1), mRNA” Genbank GI No. 18601083, May 13, 2002.
NCBI Annotation Project, “Homo sapienscoactivator-associated arginine methyltransferase-1 (CARM1), mRNA. ” Genbank GI No. 14759767, Oct. 16, 2001.
NCBI Annotation Project, “Homo sapienshypothetical protein FLJ10559 (FLJ10559), mRNA.” Genbank GI No. 11422727, Oct. 16, 2001.
Frankel,A., et al., “Homo sapiensprotein arginine N-methyltransferase 6 (PRMT6), mRNA.” Genbank GI No. 8922514, Feb. 10, 2002.
NCBI Annotation Project, “Homo sapiensprotein arginine N-methyltransferase 6 (PRMT6), mRNA.” Genbank GI No. 17436208, May 8, 2002.
Strausberg,R., “Homo sapiens, hypothetical protein FLJ10559, clone MGC:3421 Image:3629812, mRNA, complete cds.”, Genbank GI No. 12803778, Jul. 12, 2001.
Chen,D., et al., “protein arginine methyltransferase [Mus musculus].” Genbank GI No. 5257221, Jun. 28, 1999.
NCBI Annotation Project, “coactivator-associated arginine methyltransferase-1 [Homo sapiens].” Genbank GI No. 18601084, May 13, 2002.
NCBI Annotation Project, “coactivator-associated arginine methyltransferase-1 [Homo sapiens].” Genbank GI No. 14759768, Oct. 16, 2001.
NCBI Annotation Project, “hypothetical protein FLJ10559 [Homo sapiens].” Genbank GI No. 11422728, Feb. 09, 2001.
Frankel,A., et al., “hypothetical protein FLJ10559 [Homo sapiens].” Genbank GI No. 8922515, feb. 10, 2002.
Han, K. et al., S-Adenosylmethionine: Protein-Arginine N-Methyltransferase from Bovine Fetal Liver, Biochemical Archives, 1999, pp. 45-57, vol. 15.
Lin, Q. et al., Design of Allele-Specific Protein Methyltransferase inhibitors, J. Am. Chem. Soc., Nov. 28, 2001, pp. 11608-11613, vol. 123, No. 47.
Koh, S.S. et al., Synergistic Enhancement of Nuclear Receptor Function by p160 Coactivators and Two Coactivators with Protein Methyltransferase Activities, The Journal of Biological Chemistry, Jan. 12, 2001, pp. 1089-1098, vol. 276, No. 2.

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