Printing molecular library arrays using deprotection agents sole

Details Printing molecular library arrays using deprotection agents sole Printing molecular library arrays using deprotection agents sole

1995-02-27

1997-02-04

Jones, W. Gary

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

536 253, 436518, 530333, 530334, 530335, C12P 1934, G01N 33543, C07H 2102, C07K 500

Patent

active

055996957

ABSTRACT:
A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.

REFERENCES:
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5242974 (1993-09-01), Holmes
patent: 5514789 (1996-05-01), Kempe
Maskos et al, (1993), "A novel method for the analysis of multiple sequence variants by hybridization to oligonucleotides", Nucleic Acids Res. 21(9):2267-2268.
Atkinson et al, (1984), "Solid-phase Synthesis of oligodeoxyribonucleotides by the phoosphite-triester method" in Gait, M. J. (ed.), Oligonucleotide synthesis-A Practical Approach, IRL Press, Oxford, pp. 35-81.
Bray et al, (1994), "Simultaneous multiple synthesis of peptide amides by the multipin method. Application of vapor-phase ammonolysis", J. Org. Chem. 59:2197-2203.
Feldman et al, (1994), "Gray code masks for sequencing by hybridization", Genomics 23:233-235.
A. Bray et al., J. Org. Chem. 59:2197-2203 (1984).
E. Kaiser et al., Science 243:187-192 (Jan. 1989).

Affiliated with

Also associated with

Rating

Printing molecular library arrays using deprotection agents sole does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Printing molecular library arrays using deprotection agents sole, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Printing molecular library arrays using deprotection agents sole will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-677659