Drug – bio-affecting and body treating compositions – Dentifrices – Oxygen or chlorine releasing compound containing
Patent
1995-01-18
1997-08-12
McKane, Joseph
Drug, bio-affecting and body treating compositions
Dentifrices
Oxygen or chlorine releasing compound containing
424 51, 424 52, 424 54, 424 56, 514365, 514367, 548152, 548161, 548164, 548179, 548180, 548190, 548193, 548194, 548202, 548203, 548204, 548205, A61K 3138, C07D27724
Patent
active
056562616
ABSTRACT:
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reversing, the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.
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Cerami Anthony
Egan John J.
Hwang San-Bao
Ulrich Peter C.
Vasan Sara
Alteon Inc.
McKane Joseph
The Picower Institute for Medical Research
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