Preparing essentially monomeric normal human serum albumin

Details Preparing essentially monomeric normal human serum albumin Preparing essentially monomeric normal human serum albumin

1992-03-09

1993-10-05

Wityshyn, Michael G.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

530362, 530363, C07K 324, C07K 1506

Patent

active

052506630

ABSTRACT:
A composition is disclosed which comprises a solution of human serum albumin essentially free of chemicals used in processing. The preparation is also essentially free of metals such as aluminum. The composition is 100% pure by cellulose acetate electrophoresis and is essentially monomeric when tested by high pressure liquid chromatography. The turbidity is less than 5 N.T.U. (National Turbidity Units). This preparation has a substantially longer shelf life and remains biologically active longer than products currently available. The novelty of this product is also such that it does not leach metallic substances such as aluminum from its closure. Novel applications of process methodology are taught in the preparation of this composition and a novel preparation results from essentially non hemoglobin containing albumin sources such as Source Plasma (Human).

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Schneider et al., "An Alternative Method of Large Scale Plasma Fractionation . . . ", Blut, vol. 30, pp. 121-134 (1975).

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