Preparation process of .alpha.-aspartyl-L-phenylalanine methyl e

Details Preparation process of .alpha.-aspartyl-L-phenylalanine methyl e Preparation process of .alpha.-aspartyl-L-phenylalanine methyl e

1993-09-30

1995-06-13

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C20906

Patent

active

054244773

ABSTRACT:
.alpha.-L-Aspartyl-L-phenylalanine methyl ester (.alpha.-APM) is prepared by catalytic hydrogenation of N-benzyloxycarbonyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester (Z-.alpha.-APM). The catalytic hydrogenation is conducted in an aqueous suspension containing the Z-.alpha.-APM in the form of particles whose average particle size is not greater than 800 .mu.m. The starting Z-.alpha.-APM may contain up to 30 wt. % of its .beta.-isomer provided that the process additionally includes recrystallization of the .alpha.-APM, collection of the .alpha.-APM by filtration and recycling of the filtrate for use in the aqueous suspension of Z-.alpha.-APM.

REFERENCES:
patent: 3808190 (1974-04-01), Dahlmans et al.
patent: 3879372 (1975-04-01), Boesten
patent: 4638081 (1987-01-01), Elefante
patent: 4900863 (1990-02-01), Schmidt et al.
patent: 4994605 (1991-02-01), Kishimoto et al.
Pine et al., "Organic Chemistry", 4th Ed. (1980) McGraw-Hill Book Company, N.Y., pp.804-805.
House, "Modern Synthetic Reactions", 2 Ed., (1972) Benjamin/Cummings Pub., Mass. pp. 1-3.

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