Preparation of stereochemically pure oximes with muscarinic acti

Details Preparation of stereochemically pure oximes with muscarinic acti Preparation of stereochemically pure oximes with muscarinic acti

1994-06-10

1996-05-07

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548128, 548131, 546238, 546272, 544143, 544212, 544373, C07D48708

Patent

active

055148123

ABSTRACT:
The instant invention is a selective formation of the Z-oxime and O-alkylation of 1-azabicyclo 2.2.1!heptan-3-one and 1-azabicyclo 2.2.2!heptan-3-one oximes to produce compounds with muscarinic activity. The process is capable of scale-up for industrial purposes as it provides better yields and ease of preparation. Intermediates are also described.

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