Preparation of a piperidinylcyclopentylheptenoic acid derivative

Details Preparation of a piperidinylcyclopentylheptenoic acid derivative Preparation of a piperidinylcyclopentylheptenoic acid derivative

1988-06-21

1990-06-12

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21134

Patent

active

049334611

ABSTRACT:
A process is described for the preparation of a compound of formula (1) ##STR1## or a salt thereof, which comprises reacting a compound of formula (2) ##STR2## (where A is a displaceable atom or group and R is a hydrogen atom or a C.sub.1-6 alkyl or C.sub.7-20 aralkyl protecting group) or a salt thereof, to replace the moiety A with a phenyl group, followed where necessary by removal of a C.sub.1-6 alkyl or C.sub.7-20 aralkyl protecting group and/or by salt formation. The replacement of A in formula (2) by a phenyl group may be effected with a compound PhX (3) wherein Ph represents a phenyl and X is an atom or group as defined for A in formula (2) or X is a metal atom or metal-containing group or a group SiR'.sub.3 (where R' is an alkyl or aryl group) provided that when A is --B(OH).sub.2 X can only represent a conventional leaving group.

REFERENCES:
patent: 4342756 (1982-08-01), Collington et al.
Miyaura et al., Synthetic Communications, 11(7), pp. 513-519, 1981.

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