Anthracycline derivatives having inhibitory activity against rev

Details Anthracycline derivatives having inhibitory activity against rev Anthracycline derivatives having inhibitory activity against rev

1988-09-23

1991-03-26

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1524

Patent

active

050030558

ABSTRACT:
As new compounds are now provided 14-O-(3,4-disubstituted benzoyl)adriamycins which are of low cytotoxicity and exhibit a high activity inhibitory to the reverse transcriptase of human immunodeficiency virus (HIV) and which can inhibit propagation of HIV.

REFERENCES:
Arcamone et al., "Synthesis and Biological Evaluation of Some 14-O-Aryl Derv. of Adriamycin", J. of Medicinal Chemistry, (1974) vol. 17(3) pp. 335-337.

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