Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1992-01-24
1993-08-10
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
548531, 549 71, 558414, 560 9, 560 56, 560 61, 560100, 560102, 560105, 560125, 560126, 560128, 560147, 562496, C07B 5700
Patent
active
052351017
ABSTRACT:
An improved process for the separation of enantiomers of a mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves adding an inert liquid to the reaction solution formed by: (i) forming a salt solution comprising said racemic mixture of a C.sub.1 to C.sub.6 linear or branched aliphatic carboxylic acid and an organic or inorganic base; (ii) treating said salt solution with less that equimolar equivalents of a chiral organic nitrogenous base; (iii) precipitating from the reaction solution formed in step (ii) the less soluble diastereomeric salt; (iv) addition of a countersolvent to the slurry formed in step (iii); (v) extracting the more soluble diastereomeric salt or the salt of carboxylic acid and the base added in step (i) into the countersolvent. The inert liquid and the countersolvent must be of sufficiently different density. The inert liquid is substantially immiscible with the countersolvent and does not dissolve appreciable quantities of the precipitated less soluble diastereomeric salt.
REFERENCES:
patent: 4694100 (1987-09-01), Shimizu et al.
patent: 4723033 (1988-02-01), Erickson
patent: 4752417 (1988-06-01), Inoue et al.
patent: 4831147 (1989-05-01), Russell
patent: 4973745 (1990-11-01), Blaschke et al.
patent: 4983765 (1991-01-01), Lukas et al.
patent: 5015764 (1991-05-01), Manimaran et al.
Choudhury Azfar A.
Kadkhodayan Abbas
Patil Deepak R.
Clarke Vera C.
Dees Jos,e G.
Ethyl Corporation
Hammond Richard J.
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