Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-11-05
2000-05-02
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
530412, 514 8, C12N 1512, C07K 1447, A61K 3817
Patent
active
060571314
ABSTRACT:
Provided are methods of making preparations of recombinant soluble Complement Receptor type 1 (sCR1) defined with respect to the distribution of sCR1 glycoforms and therapeutic methods using them. The preparations are suitable for treatment of allograft or xenograft rejection, diseases involving inflammation or inappropriate complement activation, and thrombotic or shock state conditions. Preferred methods employ sCR1 glycoforms that are sialylated, have a pI of .ltoreq.5.1, or have a sialic acid: mannose molar ratio of .gtoreq.0.25.
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Freeman Anne Mary
Gosselin Michael L.
Lifter John
Marsh, Jr. Henry C.
Smith Richard A. G.
AVANT Immunotherapeutics, Inc.
Fitzgerald David L.
Yankwich Leon R.
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