Predicting hepatotoxicity using cell based assays

Chemistry: molecular biology and microbiology – Condition responsive control process

Reexamination Certificate

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C435S006120, C435S025000, C435S034000, C435S040500, C435S325000, C435S370000, C435S455000

Reexamination Certificate

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10623486

ABSTRACT:
Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.

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