Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1994-07-27
1996-07-09
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4242301, 4242021, 4242291, 514 12, A61K 39245, A61K 3800, A61K 3925, A61K 39295
Patent
active
055342582
ABSTRACT:
A vaccine is disclosed for the prophylaxis against pathogenic development of atherosclerotic plaque in a mammalian subject susceptible thereto which comprises:
(a) 10 to 30% by weight of the compound ##STR1## (b) 10 to 30% by weight of the compound ##STR2## (c) 10 to 30% by weight of the compound ##STR3## (d) 10 to 30% by weight of the compound ##STR4## in combination with a pharmaceutically acceptable inert carrier.
REFERENCES:
patent: 4038381 (1977-07-01), Perlant
Melnick et al. 1990. Possible Role of Cyromegalovirus in Atherogenesis. JAMA. 263(16): 2204-2207.
Petrie et al. 1987. Nucleic Acid Sequences of Cytomegalovirus in Cells . . . J. Infect. Dis. 155(1): 158-159.
Weston et al. 1986. Sequence of the Short Unique Region, Short Repeats . . . J. Gol. Biol. 192: 177-208.
Fabricant et al. 1983. Herpesvirus-Induced Atherosclerosis in Chickens. FASEB, Fed. Proc. 42: 2476-79.
Fabricant et al. 1981. Vaccination Prevents Atherosclerosis Induced by Marek's . . . FASEB Mtg. Abstract p. 335, Abs #583.
McGloch et al. 1986. Complete DNA Sequence of the Short Repeat Region in the Genone . . . Nucleic Acids Res. 14(4): 1727-45.
Lerner et al. In: Biology of Immunologic Disease ed. Dixon et al. pp. 331-338.
Hendrix et al. 1989. The Presence of Cyoomegalovirus Nucleic Acids in Arterial Walls . . . Am. J. Pathol. 134(5): 1151-57.
Benditt et al. 1983. Viruses in the Etiology of Atherosclerosis PNAS, USA. 80: 6386-89.
Fabricant et al. 1978. Virus-Induced Atherosclerosis J. Exp. Med. 148: 335-40.
Hendrix et al. 1990. High Prevalence of Latently Present Cytomegalovirus . . . ATN. J. Pathol. 136: 23-28.
Chaihorsky Alexander
Golubev Daniel B.
Bio-Virus Research Incorporated
Dubno Herbert
Housel James C.
Minnifield N. M.
Myers Jonathan
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