Polypeptides and process for producing the same

Details Polypeptides and process for producing the same Polypeptides and process for producing the same

1976-05-03

1978-04-25

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

040862216

ABSTRACT:
Polypeptides of the formula ##STR1## wherein A.sub.1 is Ser or Gly, A.sub.7 is Val or Met, A.sub.10 is Lys or Thr, A.sub.11 is Leu or Tyr, A.sub.12 is Ser or Thr, A.sub.14 is Glu or Asp, A.sub.15 is Leu or Phe, A.sub.16 is His or Asn, A.sub.18 is Leu or Phe, A.sub.19 is Gln or His, A.sub.21 is Tyr or Phe, A.sub.23 is Arg or Gln, A.sub.25 is Asp or Asn or Ala, A.sub.26 is Val or Thr or Ile, A.sub.28 is Ala or Ser or Val, and A.sub.30 is Thr or Val or Ala, and pharmaceutically acceptable acid addition salts and complexes, have serum calcium reducing activity.

REFERENCES:
patent: 3798203 (1974-03-01), Brugger et al.
patent: 3891614 (1975-06-01), Sakakibara et al.
J. Med. Chem., 18, (1975), pp. 124-126.

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