Polypeptide intermediates

Details Polypeptide intermediates Polypeptide intermediates

1986-04-16

1987-08-04

Brown, Johnnie R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530329, C07K 716

Patent

active

046847162

ABSTRACT:
2- or 3-.beta.-Indolylalanyl and .beta.-indolylglycyl vasopressins are prepared by standard peptide synthetic methods. These 2- or 3-TRP vasopressins have vasopressin antagonist activity.

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M. Manning et al., Nature, 308 652 (1984).
M. Lebl et al., Proceedings of the 17th European Peptide Symposium, 1982.
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Chemical Abstracts, vol. 83, 67 (1975) (Abstract No. 172906e).
Chemical Abstracts, vol. 85, 67 (1976) (Abstract No. 57024v).
Schroder and Lubke, The Peptides, vol. II, Academic Press, N.Y. 1966, pp. 366-373.
W. Rittel et al., Experientia, 32(2), 246-248 (1976).
Morrison and Boyd, Organic Chemistry, Allyn and Bacon, p. 1135 (1975).

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