Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
1998-07-15
2001-03-13
Carlson, Karen Cochrane (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S252300, C435S006120, C436S094000, C536S023100
Reexamination Certificate
active
06200776
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to newly identified polypeptides and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be agonists, antagonists and/or inhibitors which are potentially useful in therapy, and to production of such polypeptides and polynucleotides.
BACKGROUND OF THE INVENTION
The drug discovery process is currently undergoing a fundamental revolution as it embraces ‘functional genomics’, that is, high throughput genome- or gene-based biology. This approach as a means to identifying genes and gene products as therapeutic targets is rapidly superceding earlier approaches based on ‘positional cloning’. A phenotype, that is a biological function or genetic disease, would be identified and this would then be tracked back to the responsible gene, based on its genetic map position.
Functional genomics relies heavily on high throughput DNA sequencing technologies and the various tools of bioinformatics to identify gene sequences of potential interest from the many molecular biology databases now available. There is a continuing need to identify and characterise further genes and their related polypeptides/proteins, as targets for drug discovery.
SUMMARY OF THE INVENTION
The present invention relates to hNBC3, in particular hNBC3 polypeptides and hNBC3 polynucleotides, recombinant materials and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides, including the treatment of ischaemic heart disease, arrhythmias, congestive heart disease, stroke and renal ischaemia, hereinafter referred to as “the Diseases”, amongst others In a further aspect, the invention relates to methods for identifying agonists and antagonists/inhibitors using the materials provided by the invention, and treating conditions associated with hNBC3 imbalance with the identified compounds. In a still further aspect, the invention relates to diagnostic assays for detecting diseases associated with inappropriate hNBC3 activity or levels.
REFERENCES:
Grichtchenko et al. GenBank110 Database. Accession No. AF069512. Homo sapiens sodium bicarbonate cotransporter (NBC) mRNA, complete cds, Dec. 1998.
Watson et al. Molecular Biology of the Gene, 4th edition. Inside cover, 1987.
GenBank Accession # AF007216 Homosapiens sodium bicarbonate cotransporter (HNBC1) mRNA, complete cds.
GenBank Accession # AF001958 Ambystrone tigrinum electrogenic Na+bicarbonate cotransporter (NBC) mRNA, complete cds.
GenBank Accession # AF027362 Rathus narvegicus sodium bicarbonate cotransporter (rNBC1) mRNA, complete cds.
Burnham, C.F. et al., “Cloning and Functional Expression of a Human Kidney Na+:HCO3Cotransporter”, J. Biol. Chem., vol. 272 (31), pp. 19111-19114 (1997).
Romero et al., “Expression cloning and characterization of a renal electrogenic Na+/HCO-3cotransporter” Nature vol. 387, pp. 409-413 (1997).
Boron et al., “The Renal Electrogenic Na+:HCO3—Cotransporter”, Journal of Experimental Biology, vol. 200, pp. 263-268 (1997).
Romero et al., “Cloning and Functional Expression of the Rat Renal Electrogenic Na/HCO3 Cotransporter” Journal of the American Society of Nephrology, vol. 7 (9) p. 1259 (1996).
Boron Walter F
Bril Antoine Michel Alain
Doe Trudy Rachel
Jupe Steven Charles
Khandoudi Nassirah
Carlson Karen Cochrane
Han William T.
King William T.
Ratner & Prestia
Srivastava Devesh
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