Polynucleotides encoding human G-protein coupled receptor GPRZ

Details Polynucleotides encoding human G-protein coupled receptor GPRZ Polynucleotides encoding human G-protein coupled receptor GPRZ

1995-06-06

1999-12-07

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 697, 4352523, 4353201, 536 234, 536 235, C12N 1512, C12N 1562

Patent

active

059981644

ABSTRACT:
Human G-protein coupled receptor or polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

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