Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-07-24
2007-07-24
Nashed, Nashaat (Department: 1656)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069200, C435S069700, C435S252300, C435S320100, C536S023400
Reexamination Certificate
active
09993180
ABSTRACT:
The present invention provides novel polynucleotides encoding LSI-01 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LSI-01 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
REFERENCES:
patent: 5955284 (1999-09-01), Braxton et al.
patent: 6008020 (1999-12-01), Hastings et al.
patent: 6753164 (2004-06-01), Ni et al.
patent: 2002/0160491 (2002-10-01), Ni et al.
patent: 2003/0027272 (2003-02-01), Baker, et al.
patent: 2003/0032102 (2003-02-01), Baker, et al.
patent: 2003/0036143 (2003-02-01), Baker, et al.
patent: 2003/0036156 (2003-02-01), Baker, et al.
patent: 2003/0036157 (2003-02-01), Baker, et al.
patent: 2003/0036162 (2003-02-01), Baker, et al.
patent: WO9811134 (1998-03-01), None
patent: WO0012708 (2000-03-01), None
patent: WO0078961 (2000-12-01), None
patent: WO0132874 (2001-05-01), None
patent: WO0149715 (2001-07-01), None
patent: WO 2001/55390 (2001-08-01), None
patent: WO0155390 (2001-08-01), None
patent: WO0166690 (2001-09-01), None
patent: WO0168848 (2001-09-01), None
patent: WO0200690 (2002-01-01), None
patent: WO0202603 (2002-01-01), None
patent: WO0208284 (2002-01-01), None
patent: WO0214358 (2002-02-01), None
patent: WO02072769AW (2002-09-01), None
Frazer, J.K., et al., 2000, “Identification of centerin: a novel human germinal center B cell-restricted serpin”, European Journal of Immunology, vol. 30, pp. 3039-2048.
NCBI Entrez Accession No: gil18583071.
Frazer, et al. (2000) European Journal of Immunology 30:3039-3048.
Database EMBL Online, Aug. 8, 2000, Baker, et al. “Human PR01337 (UNQ692)” retrieved from EBI, Database Accession No. AAY99407, XP002229973.
Altschul, et al., “Basic Alignment Search Tool”, J. Mol. Biol, vol. 215, pp. 403-410 (1990).
Backes, et al., “Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin”, Nature Biotechnology, vol. 18, pp. 187-193 (2000).
Balasubramanian, et al., “Active Site-Directed Synthetic Thrombin Inhibitors: Synthesis, in Vitro and in Vivo Activity Profile of BMY 44621 and Analogs. An Examination of the Role of the Amino Group in the D-Phe-Pro-Arg-H Series”, J. Med. Chem., vol. 36, pp. 300-303 (1993).
Bateman, et al., “The Pfam Protein Families Database”, Nucleic Acids Research, vol. 28(1), pp. 263-266 (2000).
Baumann, et al., “Crystal Structure of Cleaved Human α1-Antichymotrypsin at 27 A Resolution and its comparison with Other Serpins”, J. Mol. Biol., vol. 218, pp. 595-606 (1991).
Blinder, et al., “Site-directed Mutagenesis of Arginine 103 and Lysine 185 in the Proposed Glycosaminoglycan-binding Site of Herparin Cofactor II”, J. Biol. Chem., vol. 265(1), pp. 286-291 (1990).
Blinder, et al., “Heparin Cofactor IIOslo, Mutation of ARG-189 To His Decreases The Affinity for Dermatan Sulfate”, J. Biol. Chem., vol. 264(9), pp. 5128-5133 (1989).
Bohm, Hans-Joachim, “The computer program LUDI: A new method for the de novo design of enzyme inhibitors”, J. Computer-Aided Molecular Design, vol. 6, pp. 61-78 (1992).
Cajot, et al., “Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells”, PNAS, vol. 87, pp. 6939-6943 (1990).
Cardozo, et al., “Homology Modeling by the ICM Method”, Proteins, vol. 23, pp. 403-414 (1995).
Carrell, et al., “The Serpins: Evolution and Adaptation in a Family of Protease Inhibitors”, Cold Spring Harbor Symposia on Quantitative Biology, vol. LII, pp. 527-535 (1987).
Carrell, et al., “α1-Antitrypsin and the serpins: variation and countervariation”, TIBS, pp. 20-24 (1985).
Chai, et al., “Molecular Cloning, Sequence Analysis, and Chromosomal Localization of the Human Protease Inhibitor 4 (Kallistatin) Gene (P14)”, Genomics, vol. 23, pp. 370-378 (1994).
Chai, et al., “Kallistatin: A Novel Human Serine Proteinase Inhibitor”, J. Biol. Chem., vol. 268 (32), pp. 24498-24505 (1993).
Chandra, et al., “Sequence Homology between Human”α1- Antichymotrypsin, α1-Antitrypsin, and Antithrombin III, Biochem., vol. 22(22), pp. 5055-5061 (1983).
Chen, Wen-Tien, “Membrance proteases:roles in tissue remodeling and tumour invasion”, Curr. Opin. Cell Biol., vol. 4, pp. 802-809 (1992).
Clarke, et al., “Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins”, Biochemica Biophysica Acta, vol. 1129, pp. 246-248 (1992).
Clark, et al., “The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment”, Genome Res., vol. 13, pp. 2265-2270 (2003).
Combrink, et al., “1,2-Benzisothiazol-3-one 1,1-Dioxide Inhibitors of Human Mast Cell Tryptase”, J. Med. Chem., vol. 41, pp. 4854-4860 (1998).
Cooper, et al., “Phosphorylation Sites in Enolase and Lactate Dehydrogenase Utilized by Tyrosine Protein Kinases in Vivo and in Vitro”, J. Biol. Chem., vol. 259(12), pp. 7835-7841 (1984).
Dano, et al., “Plasminogen Activators, Tissue Degradation, and Cancer”, Advances in Cancer Research, vol. 44, pp. 139-266 (1985).
Feramisco, et al., “Optimal Spatial Requirements for the Location of Basic Residues in Peptide Substrates for the Cyclic AMP-dependent Protein Kinase”, J. Biol. Chem., vol. 255(9), pp. 4240-4245 (1980).
Foekens, et al., “Prognostic Value of Urokinase-type Plasminogen Activator in 671 Primary Breast Cancer Patients”, Cancer Res., vol. 52, pp. 6101-6105 (1992).
Flink, et al., “Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: Close homology to the serine antiproteases”, PNAC, vol. 83, pp. 708-7712 (1986).
Forgue-Lafitte, “Effects of Ketoconazole on the Proliferation and Cell Cycle of Human Cancer Cell Lines”, Cancer Res., pp. 6827-6831 (1992).
Foucre', et al., “Relationship between cathepsin D, urokinase, and plasminogen activator inhibitors in malighant vs. benign breast tumours”, Br. J. Cancer, vol. 64, pp. 926-932 (1991).
Gils, et al., “Structure-function Relationships in Serpins: Current Concepts and Controversies”, Thromb. Haemost., vol. 80, pp. 531-541 (1998).
Glass, et al., “Phosphorylation by Cyclic GMP-dependent Protein Kinase of a Synthetic Peptide Corresponding to the Autophosphorylation Site in the Enzyme”, J. Biol. Chem., vol. 258(24), pp. 14797-14803 (1983).
Glass, et al., “Synthetic Peptides Corresponding to the Site Phosphorylated in 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase as Substrates of Cyclic Nucleotide-dependent Protein Kinases”, J. Biol. Chem., vol. 261(6), pp. 2987-2993 (1986).
Goodford, P.J., “A Computational Procedure for Determining Energetically Favorable Binding Sites on Biologically Important Macromolecules”, J. Med. Chem., vol. 28, pp. 849-857 (1985).
Goodsell, et al., “Automated Docketing of Substrates to Proteins by Simulated Annealing”, Proteins, vol. 8, pp. 195-202 (1990).
Grand, Roger, J.A., “Acylation of viral and eukaryotic proteins”, Biochem. J., vol. 258, pp. 625-638 (1989).
Heidtmann, et al., “Synthesis and Secretion of Plasminogen Activators and Plasminogen Activator Inhibitors in Cell Lines of Different Groups of Human Lung Tumors”, Cancer Res., vol 49, pp. 6960-6965 (1989).
Hendl
Chen Jian
Cheney Daniel L.
Nelson Thomas
Bristol--Myers Squibb Company
D'Amico Stephen C.
Loring Denise L.
Mangasarian Karen
Moore William W.
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