Polymorphic forms of a growth hormone secretagogue

Details Polymorphic forms of a growth hormone secretagogue Polymorphic forms of a growth hormone secretagogue

1996-10-23

1998-06-16

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 17, A61K 31445, C07D40102

Patent

active

057671249

ABSTRACT:
This invention is concerned with polymorphic forms of the compound l)carbonyl!-2-(phenylmethyloxy)ethyl!-2-amino-2-methylpropanamide methanesulfonate which is a growth hormone secretagogue that is useful in food animals to promote their growth thereby rendering the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, and to treat medical conditions which are improved by the anabolic effects of growth hormone. The instant polymorphic forms have advantages over the other known forms of l)carbonyl!-2-(phenylmethyloxy)-ethyl!-2-amino-2-methylpropanamide methanesulfonate in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations. The present invention is also concerned with processes for preparing these polymorphic forms, pharmaceutical formulations comprising these polymorphic forms as active ingredients and the use of the polymorphic form of the compound and their formulations in the treatment of certain disorders.

REFERENCES:
patent: 5536716 (1996-07-01), Chen et al.
Patchett, A.A., et al., Proc. Natl. Acad. Sci. USA, 92, pp. 7001-7005 (1995).

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