Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-08-13
2000-12-12
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514248, 544239, A61K 31502, C07D23730
Patent
active
06159976&
ABSTRACT:
This invention relates to zopolrestat monohydrate and polymorphs thereof. This invention also relates to processes for preparing zopolrestat monohydrate, for preparing polymorphs thereof and for preparing anhydrous zopolrestat. This invention also relates to compositions comprising zopolrestat monohydrate and to methods of using zopolrestat monohydrate and compositions thereof to treat diabetic complications such as diabetic cataracts, diabetic retinopathy or diabetic neuropathy, lower blood lipid levels or blood uric level.
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patent: 4904782 (1990-02-01), Sinay, Jr. et al.
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patent: 4954629 (1990-09-01), Mylari et al.
Mylari et al. Novel, Potent Aldose Reductase Inhibitors: 3,4-Dihydro-4-oxo-3[5-trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalaz ine-acetic Acid (Zopolrestat) and Congeners, J. Med. Chem., 34, pp. 108-122, 1991.
Mylari et al., J. Med. Chem., 1991, 34, 108-122.
Lambert John F.
Norris Timothy
Benson Gregg C.
Kleiman Gabriel L.
Pfizer Inc.
Richardson Peter C.
Schroeder Ben
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