Polymers having benzeneboronic acid groups and insulin complexes

Details Polymers having benzeneboronic acid groups and insulin complexes Polymers having benzeneboronic acid groups and insulin complexes

1993-03-26

1995-12-26

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424488, 514866, A61K 3828

Patent

active

054785758

ABSTRACT:
The present invention provides a polymer complex of a sugar response type having boronic acid groups in the polymer. Medicines may be contained or linked, preferably, the medicines have hydroxy groups. The polymer having boronic acid groups and the medicine having hydroxy groups may be linked by boronic acid ester bonds. The complex may also comprises polymers having boronic acid groups and polymers having hydroxy groups, and these polymers may be cross-linked.

REFERENCES:
Makromolekulare Chemie, Macromolecular Chemistry and Physics, vol. 175, No. 3, 1974, pp. 1007-1008.
Chemical Abstracts, vol. 92, No. 22, Jun. 1980, p. 21.
Choi et al. Int. J. of Pharm. 80 (1992) 9-16.
Majestas et al. 189 (1980) 225-231 J. of Chrom.
Journal of Chromotography 189 (1980) 225-231 Majestas et al.
Chem. Abstracts 92:397322 Shiino et al.
Chem. Abstracts 91:312133 Linder et al.
Chem. Abstracts 92:192359.

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