Polymeric temperature sensitive drug carrier

Details Polymeric temperature sensitive drug carrier Polymeric temperature sensitive drug carrier

1990-07-13

1991-10-01

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424 78, 424 81, 424487, 523122, A61K 908, A61K 3178, A61K 31765

Patent

active

050532286

ABSTRACT:
The drug carrier of this invention provides a temperature-sensitive polymer chemically bonded to a drug. The drug carrier is capable of releasing a drug continuously in the body. The drug carrier is a liquid when administered and becomes solid in the body, in which state it is capable of releasing a drug continuously. The drug carrier has a lower LCST than human body temperature.

REFERENCES:
patent: 4182695 (1980-01-01), Horn et al.
patent: 4609707 (1986-09-01), Nowinski et al.
patent: 4780409 (1988-10-01), Monji et al.
patent: 4829098 (1989-05-01), Hoffman et al.
patent: 4912032 (1990-03-01), Hoffman et al.
Hoffman et al., "Thermally Reversible Hydrogels: Delivery and Selective Removal of Substances from Aqueous Solutions," Journ. of Controlled Release, 4:213-222, 1986.
Bae et al., "Thermo-Sensitive Polymers as On-Off Switches for Drug Release," Makromol. Chem., Rapid Commun., 8:481-485, 1987.

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