Platelet activating factor antagonists, named "the phomactins",

Details Platelet activating factor antagonists, named "the phomactins", Platelet activating factor antagonists, named "the phomactins",

1992-08-10

1994-05-03

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549545, A01N 4320, A01K 31335, C07D30300

Patent

active

053088670

ABSTRACT:
A series of new compounds, called "the phomactins" is provided and may be isolated from the culture broth of fungi of the genus Phoma. especially Phomas sp. SANK 11486 (No. FERM BP-2598). These compounds are platelet activating factor antagonists and may be used for the treatment of disorders for which known such agents may also be used.

REFERENCES:
patent: 3984177 (1976-10-01), Trozzolo
patent: 4076642 (1978-02-01), Herber et al.
P. Braquet et al, "PAF-acether specific binding sites: 2.Design of specific antagonists", Oct. 1986, Trends in Pharm. Sci., vol. 7, pp. 397-403.
Okamoto, et al, "Studies of Platelet Activating Factor (PAF) Antagonists from Microbial Products. I. Bisdethiobis(methylthio)gliotoxin and Its Derivatives", 1986, Chem. Pharm. Bull., 34 340-344.
S. Takase, "Structure of FR900452, a Novel Platelet-Activating Factor Inhibitor from a Streptomyces", 1987, J. Org. Chem., 52, 3485-3487.
P. Braquet, et al, "Is there a case for PAF antagonists in the treatment of ishchemic states?", 1989, Trends in Pharm. Sci., vol. 10, pp. 23-30.

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