Tools
Patent
1990-05-03
1992-10-06
Rotman, Alan L.
Tools
546221, A61K 31445, C07D21106
Patent
active
051532077
ABSTRACT:
A piperidine derivative represented by the following general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).
REFERENCES:
patent: 4929618 (1990-03-01), Koda
Patent Abstracts of Japan vol. 11, No. 106 (C-414) (2553) Apr. 3, 1987, & JP-A-61 254559 (Terumo Corporation) Nov. 12, 1986, *the whole document*.
Ito Yasuo
Kato Hideo
Koshinaka Eiichi
Nishino Hiroyuki
Ogawa Nobuo
Chang Celia
Hokuriku Pharmaceutical Co., Ltd.
Rotman Alan L.
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