Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-09-15
1991-02-26
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514319, 514323, 514325, 514326, 514330, 514331, 514414, 514422, 514423, 546189, 546190, 546191, 546203, 546204, 546205, 546206, 546208, 546214, 546225, 546232, 548467, 548468, 548518, 548523, 548524, 548528, 548570, 548571, 548575, 548576, 548578, A61K 3140, A61K 31435, C07D20709, C07D21128
Patent
active
049962159
ABSTRACT:
A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R.sup.1 is a lower alkyl or a tolyl, R.sup.2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R.sup.3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is --CO--, --CH.sub.2 -- or --CHOH--, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, --CH.sub.2 COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, ##STR2## l being 1 or 2, --A--B, A being --(CH.sub.2).sub.n --, n being an integer of 1 to 5, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, --(CH.sub.2).sub.k --S--, k being an integer of 2 to 5, --(CH.sub.2).sub.p --CO--, p being an integer of 1 to 4, B being cyano, --NR.sub.4 R.sub.5, a heterocyclic ring or a condensed aromatic ring.
REFERENCES:
patent: 4876262 (1989-10-01), Oinuma et al.
Daiku Yoshiharu
Hoshiko Tomonori
Minami Norio
Miyake Kazutoshi
Nomoto Ken-ichi
Brust Joseph Paul
Eisai Co. Ltd.
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