Piperazino derivatives as neurokinin antagonists

Details Piperazino derivatives as neurokinin antagonists Piperazino derivatives as neurokinin antagonists

1996-08-30

1999-04-06

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544364, 544357, 544387, 514252, 514253, 514255, A61K 31495, C07D40102, C07D40114

Patent

active

058920390

ABSTRACT:
The invention relates to compounds of the formula ##STR1## These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

REFERENCES:
patent: 3935214 (1976-01-01), Zellner
patent: 4935419 (1990-06-01), Bjork et al.
patent: 5350852 (1994-09-01), Emonds-Alt et al.
patent: 5464788 (1995-11-01), Bock et al.
patent: 5654316 (1997-08-01), Carruthers et al.
patent: 5688960 (1997-11-01), Shankar
patent: 5691362 (1997-11-01), McCormick et al.
patent: 5719156 (1998-02-01), Shue et al.
patent: 5795894 (1998-08-01), Shue et al.
J. Med. Chem., 9 (1966), p. 181, Roderick et al..
Maggi et al, Eur. J. Pharmacol., 166, (1989), p. 435-440.
Ellis et al, J. Pharmacol. Exp. Ther., 267, 1 (1993), p. 95-101.
Furchgott, Pharm. Rev., 7 (1955), p. 183-265.
Arunlakshana et al, Brit. J. Pharmacol., 14, 48 (1959), p. 48-58.
Danko et al, Pharmacol. Comm., 1, 3 (1992), p. 203-209.
Frossard et al., Life Sciences vol. 49, pp. 1941-1953 (1991).

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