Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-09-01
1992-02-25
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514250, 544230, 544344, A61K 31495, C07D24136
Patent
active
050914278
ABSTRACT:
The invention relates to compounds of the formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R.sup.2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring .alpha.-amino acid, R.sup.4 can additionally represent ##STR2## R.sup.3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R.sup.3 and R.sup.4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system,
REFERENCES:
Donalds Medical Dictionary, p. 296, 1958.
Cecil's Textbook in Medicine, p. 1979, 1983.
Khandelwal et al., "Agents Acting on CNS . . . ", Ind. J. Chem. 16B, 1015-18 (1978).
Occelli et al., "CNS Active Substance . . . ", CA 101:211099j (1984).
Kasafirek et al., "Spiro-2,5-Piperazinedione . . . ", CA 106: 33473s (1987).
Tanhiguchi (Formula IV) CA 105: 191590m (1986).
Berlhet (Formula IV) CA 105: 191593q (1986).
Arnold B. Scheibel et al., The Biological Substrates of Alzheimer's Disease, Academic Press, 1986, London, New York 3ff.
U. Schindler et al., Nootropic Drugs: Animal Models for Studying Effects on Cognition, Drug Development Research 4:567-576 (1984).
R. T. Bartus, et al., Logical Principles for the Development of Animal Models of Age-Related Memory Impairments, Assessment in Geriafric Psychopharmacology, published by Mark Pauley Associates, Inc., 88 Main Street, New Cannan, Conn., U.S.A., Dec. 1983, pp. 263-299.
G. Pepeu, The Relationship Between the Behavioral Effects of Cognition-Enhancing Drug and Brain Acetylcholine, Pharmacopsychiat, 22, 116-119, (1989).
Henning Rainer
Hock Franz
Lerch Ulrich
Nickel Wolf-Ulrich
Ruger Wolfgang
Chang Celia
Hoechst Aktiengesellschaft
Ivy C. Warren
LandOfFree
Piperazinediones having a psychotropic action does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Piperazinediones having a psychotropic action, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperazinediones having a psychotropic action will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1893400